Genome News Network: New Amino acid Discovered in Methanosarcina barkeri
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Description: Reports on the discovery of a new amino acid, pyrrolysine, coded by UAG (normally a stop codon) in this methanogen.
(May 25, 2002)
New amino acid discovered in Methanosarcina barkeri The discoverers of a new amino acid report that a stop sign is not always a stop sign. The amino acid, called pyrrolysine, is genetically encoded by a nucleotide sequence that normally halts the translation of mRNA—a stop codon. But during the assembly of certain proteins, the researchers found, cells override the stop codon, incorporate pyrrolysine, and continue to synthesize protein.
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