Prion Helical Wheels
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Description: Java applet to illustrate alpha-helices, using a traditional helical wheel. Output as Postscript, JPEG, GIF or PICT.
Prion protein contains three alpha-helical stretches, according to the 3D-NMR structural fragment described in the 11 July 1996 Nature. The first helix was anomalous in not being amphipathic: normally, looking down the axis of an alpha helix in the 'helical wheel' projection, one sees polar surface residues on one side and hydrophobic interior residues on the other. Amphipathic refers to these two faces. The problem with helix H1 can be seen clearly from a
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