Biological Effects of Low Level Exposures
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Description: Studies dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in in vitro, and in vivo systems, including human populations.
BELLE - Biological Effects of Low Level Exposures : Welcome In May 1990, a group of scientists representing several federal agencies, the International Society of Regulatory Toxicology and Pharmacology, the private sector, and academia met to develop a strategy to encourage the assessment of the biological effects of low level exposures (BELLE) to chemical agents and radioactivity. The meeting was convened because of the recognition that most human exposures to chemical and physical agents are at relatively low levels, yet most toxicological studies assessing potential human health effects involve exposures to quite high levels, often orders of magnitude greater than actual human exposures. Consequently, risks at low levels are estimated by various means, frequently utilizing assumptions about which there may be considerable uncertainty.
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| Page title: | BELLE - Biological Effects of Low Level Exposures : Welcome |
| Keywords: | international hormesis society, hormesis, j-shaped, nonlinearity, calabrese, biphasic, bell-shaped, stimulation, carcinogenesis, u-shaped, low dose, dose-response, threshold, nonlinear, toxicology, non-monotonic, adaptive response, hormetic, risk assessment, novel dose-response paradigm, paradigm shift, scientific revolution, dose-response relationship, risk assessment, animal extrapolation, low-dose extrapolation, hormetic effect, paradoxical effect, nonlinear dose-response, beneficial doses |
| Description: | The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in in vitro, and in vivo systems, including human populations. While a principal emphasis of BELLE is to promote the scientific understanding of low-level effects (especially seemingly paradoxical effects), the initial goal of BELLE is the scientific evaluation of the existing literature and of ways to improve research and assessment methods. |
| IP-address: | 74.200.241.5 |
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| NS | Name Server: NS.PIONEERHOST.COM Name Server: NS2.PIONEERHOST.COM |
| WHOIS | Status: clientTransferProhibited |
| Date | Creation Date: 30-nov-1995 Expiration Date: 29-nov-2018 |