Stem Cells Portal
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Scan day: 09 February 2014 UTC
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Description: Aims to support stem cell research labs and societies worldwide, by offering access to a broad array of resources in one central location, and to aid in collaborations, discussion and networking.
Stem Cells Portal - The Stem Cells Journal Online Community Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed during embryogenesis, plays roles in development, pluripotency, and metabolism. To determine whether Lin28a might influence tissue repair in adults, we engineered the reactivation of Lin28a expression in several models of tissue injury. Lin28a reactivation improved hair regrowth by promoting anagen in hair follicles and accelerated regrowth of cartilage, bone, and mesenchymel after ear and digit injuries. Lin28a inhibits let-7 microRNA biogenesis; however, let-7 repression was necessary but insufficient to enhance repair. Lin28a bound to and enhanced the translation of mRNAs for several metabolic enzymes, thereby increasing glycolysis and oxidative phosphorylation (OxPhos). Lin28a-mediated enhancement of tissue repair was negated by OxPhos inhibition, whereas a pharmacologically induced increase in OxPhos enhanced repair. Thus, Lin28a enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics.
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| Page title: | Stem Cells Portal - The Stem Cells Journal Online Community |
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| Description: | |
| IP-address: | 108.171.172.125 |
WHOIS Info
| NS | Name Server: NS1.MDNSSERVICE.COM Name Server: NS2.MDNSSERVICE.COM Name Server: NS3.MDNSSERVICE.COM |
| WHOIS | Status: ok |
| Date | Creation Date: 15-aug-2006 Expiration Date: 15-aug-2015 |