MainScienceBiologyBiochemistry and Molecular Biology › IRESite: The Database of Experimentally Verified IRES Structures

IRESite: The Database of Experimentally Verified IRES Structures

Edit Page
Report
Scan day: 17 February 2014 UTC
34
Virus safety - good
Description: This database contains information about the experimentally studied IRES (Internal Ribosome Entry Site) segments.
IRESite: The database of experimentally verified IRES structures The IRESite database presents information about the experimentally studied IRES ( ite) segments. IRES regions are known to attract eukaryotic ribosomal translation initiation complex and thus promote translation initiation independently of the presence of the commonly utilized 5'-terminal 7mG cap structure. It is not yet clear whether the activity could be attributed to a common sequence or to a common secondary structure present in them. Such IRES regions were found in a broad range of +RNA viruses and in some eukaryotic cellular mRNAs. Certain IRESs have been predicted based on the fact that closely related viruses should share its features and indeed, their sequences are in some regions conserved enough to allow identification of a new IRES. In contrast, cellular IRESs do not have almost anything in common in terms of their sequence or secondary structure. Therefore, cellular IRESs cannot be predicted. Either way, IRESite is focused only on IRESs which have been at least to some extent experimentally proven. To allow the cross-correlation of the experimental results the IRESite database was specifically designed to store not only the primary experimental results (sequence, structure, measured values) but also the most important methodological characteristics of the experiments.
Size: 1371 chars

Contact Information

Email:
Phone&Fax:
Address:
Extended:

WEBSITE Info

Page title:IRESite: Page home
Keywords:
Description:
IP-address:195.113.57.32