Long Laboratory
Edit Page
Report
Scan day: 07 March 2014 UTC
23
Virus safety - good
Description: Focusing on cell cycle research and bone progenitor cell biology. Includes staff directory and project details.
Welcome to the homepage of the laboratory of a part of the Department of Pediatrics, Research in the lab focuses on two primary areas: Using megakaryocyte endomitosis as a model, one group within the Long Lab is exploring the mechanisms of cell cycle control. Specifically, we hypothesize that the formation of a polyploid nucleus in megakaryocytes requires the abrogation of mitosis in order to yeild a uni-nucleate polyploid cell. We have previously shown that polyploid cells undergo two novel alterations in the mitosis-initiating cdk1/cyclin B1 protein kinase complex: a marked reduction in cdk1 (cdc2) protein levels, and elevation of cyclin B levels. Efforts are under way in the lab to further characterize cyclin B1 and identify interacting proteins, with a goal of elucidating the mechanism of endomitosis in human megakaryocytes.
Size: 840 chars
Contact Information
Email: —
Phone&Fax: —
Address: —
Extended: —
WEBSITE Info
| Page title: | Long Lab Homepage |
| Keywords: | |
| Description: | |
| IP-address: | 141.211.243.44 |
WHOIS Info
| NS | Name Servers: DNS1.ITD.UMICH.EDU 141.211.144.15 DNS2.ITD.UMICH.EDU 141.211.125.15 |
| WHOIS | |
| Date | activated: 07-Oct-1985 last updated: 14-Feb-2014 expires: 31-Jul-2014 |