Bjorkman Group
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Scan day: 09 March 2014 UTC
17
Virus safety - good
Description: Studying cell surface interactions, especially in the immune system
Our laboratory is interested in protein-protein interactions, particularly those mediating immune recognition. We use X-ray crystallography and biochemistry to study purified proteins, and electron and confocal microscopy to examine protein complexes in cells. Some of our work focuses upon homologs and mimics of class I major histocompatibility complex (MHC) proteins, which normally function in peptide presentation to T cells. MHC homologs have similar three-dimensional structures, but different functions including immune functions (IgG transport by the neonatal Fc receptor, FcRn; evasion of the immune response by viral MHC mimics), and non-immune functions (regulation of iron or lipid metabolism by HFE and ZAG). We focus on three interrelated areas: (1) structure/function studies of homologs and mimics of MHC proteins; (2) cell biological studies of antibody receptors, for example, the MHC-related neonatal Fc receptor; and (3) designing antibodies with increased efficacy against HIV.
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WEBSITE Info
| Page title: | The Bjorkman Group at Caltech |
| Keywords: | 3D-structures, Bjorkman, Caltech, biology, movies, proteins, scientific research, structural biology, crystallography, biochemistry |
| Description: | Our laboratory is interested in the structure and function of molecules involved in cell surface recognition, particularly those mediating recognition in the immune system |
| IP-address: | 131.215.239.141 |