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Oncogenic Osteomalacia

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Scan day: 13 February 2014 UTC
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Description: Presentation of clinical features, pathophysiology and therapy.
Medical journals continue to publish case reports of this unusal disease, also known as tumor-induced osteomalacia. It is one of the most interesting paraneoplastic syndromes. The tumors are usually benign, vascular, small mesencymal tumors such as hemangiomas, that are difficult to locate. They frequently are found in area of the sinuses, some are in bone or skin. A few cases of metastatic prostate carcinoma and small cell carcinoma have also been assoicated with low phosphate and osteomalacia. Myeloma with light chain nephropathy can cause hypophosphatemia but this is a form of Fanconi's syndrome and does not have the same pathophysiology. The tumors can occur at any age in both genders. It may take longer than a decade to locate them.
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Name Servers: HANNA.CAC.WASHINGTON.EDU 140.142.5.5 MARGE.CAC.WASHINGTON.EDU 140.142.5.13
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activated: 04-Sep-1986
last updated: 21-Dec-2010
expires: 31-Jul-2014