The Development of Drugs for Treatment of Sleeping Sickness: A Historical Review
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Description: Article by Dietmar Steverding outlining the development of anti-sleeping sickness drugs from the discovery of the first bioactive lead compounds to the identification of more modern chemotherapeutic agents.
Parasites & Vectors | Full text | The development of drugs for treatment of sleeping sickness: a historical review parasitesandvectors.com/article/10.1186/1756/3305/3/15 Keep up to date with the latest news and content from Parasites & Vectors and BioMed Central.
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| Page title: | Parasites & Vectors | Full text | The development of drugs for treatment of sleeping sickness: a historical review |
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| Description: | Only four drugs are available for the chemotherapy of human African trypanosomiasis or sleeping sickness; Suramin, pentamidine, melarsoprol and eflornithine. The history of the development of these drugs is well known and documented. suramin, pentamidine and melarsoprol were developed in the first half of the last century by the then recently established methods of medicinal chemistry. Eflornithine, originally developed in the 1970s as an anti-cancer drug, became a treatment of sleeping sickness largely by accident. This review summarises the developmental processes which led to these chemotherapies from the discovery of the first bioactive lead compounds to the identification of the final drugs. |
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| Date | Creation Date: 14-nov-2007 Expiration Date: 14-nov-2014 |