Protein Misfolding in Prion Disease
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Scan day: 06 February 2014 UTC
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Virus safety - good
Description: Includes review of the pathogenesis of prion diseases.
(May 16, 1997)
Protein Misfolding in Prion Disease Conformations: Protein Misfolding in Prion Disease Arthur L. Horwich and Jonathan S. Weissman Novel infectious particles, termed prions, composed largely and perhaps solely of a single protein, are the likely causative agents of a group of transmissible spongiform encephalopathies that produce lethal decline of cognitive and motor function. As if the notion of a transmissible pathogenic protein is not jarring enough, evidence indicates that the responsible protein arrives at a pathogenic state by misfolding from a normal form that has ubiquitous tissue distribution. The remarkable nature of these diseases and the nature of the prion protein conversion process as we currently understand it are reviewed below.
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