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Molecular Evolution of Prions

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Description: Article about the different evolutionary pathways of bovids and humans. (May 09, 1996)
The disturbing link between the prions that cause Bovine Spongiform Encephalopathy (BSE) in cattle and Creutzfeld-Jakob disease (CJD) in humans comes from a study of the evolutionary relationships of prions in a wide variety of mammals. The normal prion found in cattle shares two biochemical features with the prion found in humans and apes. Crucially, neither of these features are found in the prion of sheep -- the prion which, when mutated, causes the disease called 'scrapie'. These biochemical features -- changes in the amino-acid sequence of the prion protein -- occur in a part of the protein thought to be involved in the onset of prion-mediated diseases such as CJD and BSE.
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Creation Date: 1996-05-18T04:00:00Z
Expiry Date: 2015-05-19T04:00:00Z