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Dana-Farber Cancer Institute: The Waldenstrom's Macroglobulinemia Program

Bing Center for Waldenstrom's Macroglobulinemia - Home October, 2013: Dear Patients, Caregivers, and Friends of the Bing Center for WM: It gives me great pleasure to introduce to you two outstanding individuals who recently joined the Bing Center for Waldenstrom’s Macroglobulinemia at the Dana Farber Cancer Institute. Many of you have had the opportunity to meet Sandra Kanan, NP and Jorge Castillo, MD, during your recent clinic visits, and I wanted to take the opportunity to formally introduce you to these bright, talented, and dedicated practitioners who will soon be leading the Waldenstrom’s clinical effort for our center.  Both individuals were recruited to our center, after national searches, in an effort to increase our capacity to care for a rapidly growing patient population. Over 1,000 patients with WM are expected to be seen this year, with representation from all over the globe. The increased visitations have been prompted by the discovery of the mutation in the MYD88 gene in WM which was discovered by the dedicated laboratory researchers of our center and reported in the New England Journal of Medicine last year. The discovery of the MYD88 mutation prompted research efforts that now have unveiled new opportunities for targeted therapy of WM, including the use of ibrutinib, an inhibitor of Bruton’s Tyrosine Kinase (BTK) which is activated by the MYD88 mutation.

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